NAD+ IV Therapy Dosage Guide: Complete Protocol for Energy, Anti-Ageing & Wellness (Mumbai 2026)

NAD+ IV therapy dosage is where most patients and most clinics get it wrong — either by dosing too fast (causing severe flushing and nausea), too low (producing no meaningful effect), or too infrequently (missing the opportunity to actually replenish cellular NAD+ levels long-term). NAD+ (nicotinamide adenine dinucleotide) is the central coenzyme in every mitochondrion in your body, driving ATP production, DNA repair and over 500 enzymatic reactions. By age 50, plasma NAD+ is roughly 50 % lower than at age 20 — and that decline underpins a large portion of age-related decline in energy, cognitive performance and tissue resilience.

If you're searching for NAD+ IV therapy dosage, how much NAD+ to infuse, NAD+ IV dose for energy, NAD+ IV dose for anti-ageing, how often should I get NAD+ IV, NAD+ IV side effects, or NAD+ IV vs oral NMN, this guide covers every protocol in clinical use. The Sculptique Aesthetics offers NAD+ IV therapy and IV drip therapy under medical supervision in Mumbai, Bandra, Khar, Andheri, South Mumbai and across India.

What is NAD+ IV therapy and why does dose matter?

NAD+ is not a peptide — it is a dinucleotide coenzyme found in every living cell. Intravenous NAD+ delivers the molecule directly into the bloodstream, bypassing the digestive system entirely for near-100 % bioavailability. Oral NAD+ supplements (NMN, NR, niacin) achieve only 10–40 % bioavailability through digestion.

NAD+ IV dosage matters because:

• Too fast an infusion rate overwhelms buffering capacity → flushing, chest tightness, nausea (the most common complaint about NAD+ IV)
• Too low a total dose → no meaningful cellular replenishment; subclinical benefit at best
• Too infrequent → NAD+ half-life in plasma is short (hours to days depending on cell type); without maintenance infusions, levels return to baseline quickly
• Oral precursors are a viable lower-cost strategy but produce more gradual, lower-peak replenishment than IV

The right NAD+ IV protocol for you depends on your goal (energy, anti-ageing, cognitive, addiction recovery), baseline health and tolerance to the infusion rate.

NAD+ IV therapy dosage — the key numbers

Standard single NAD+ IV dose: 250–500 mg of NAD+ delivered intravenously over 2–4 hours

• Introductory / first infusion: 100–250 mg over 2–3 hours — lower to assess tolerance and minimise flushing
• Standard anti-ageing / energy dose: 250–500 mg per session
• Intensive / high-dose protocol: 500–1,000 mg per session (reserved for addiction recovery, severe fatigue or post-viral syndromes; always over 4+ hours)
• Maintenance dose: 100–250 mg monthly or bi-monthly once baseline replenishment is achieved

Infusion rate is as important as dose. Rapid infusion causes the characteristic NAD+ flushing, pressure sensation and nausea. Always allow at least 2 hours for 250 mg and 4+ hours for 500 mg+. Our drip protocols at The Sculptique Aesthetics are calibrated to maximise comfort and tolerability.

NAD+ IV therapy dosage by goal

Energy, fatigue and metabolic performance

• Session dose: 250–500 mg
• Frequency: twice weekly for 4 weeks (loading), then once weekly for 4–8 weeks (maintenance)
• After loading: monthly or bi-monthly maintenance
• Stacking: pairs well with glutathione IV in the same session for mitochondrial and antioxidant support; also with Vitamin B12 and Magnesium for energy metabolism

Most patients report noticeable energy improvement after the 2nd–3rd session. Full metabolic benefit is usually clear by 4 weeks.

Anti-ageing and longevity

NAD+ is a direct activator of sirtuins (SIRT1–7) — the master regulators of cellular ageing, DNA repair and metabolic health. It also fuels PARP enzymes responsible for repairing single-strand DNA breaks that accumulate with age.

• Session dose: 250–500 mg
• Frequency: once weekly for 4–6 weeks, then monthly maintenance
• Long-term: many patients do quarterly intensive courses (4–6 weekly infusions) alternating with monthly single infusions
• Stacking: CJC-1295 / Ipamorelin GH peptides + NAD+ IV + GHK-Cu = the full anti-ageing triad at The Sculptique Aesthetics. See CJC-1295 and Ipamorelin dosage guide.

Cognitive clarity and neurological support

NAD+ fuels neuronal ATP production and supports BDNF (brain-derived neurotrophic factor) pathways. Patients using NAD+ for cognitive goals often report the most dramatic subjective response — mental clarity and focus within 2–4 sessions.

• Session dose: 500 mg (higher dose for neurological indication)
• Frequency: twice weekly for 4 weeks, then weekly for 4 weeks, then monthly
• Infusion rate: slow — 4 hours for 500 mg minimum; neurological patients often report greater flushing sensitivity

Addiction recovery and detoxification

The most intensive NAD+ IV protocols originate from addiction medicine, where high-dose infusions are used to:

• Reduce withdrawal symptoms and cravings

• Replenish NAD+ severely depleted by chronic alcohol, opioid or stimulant use

• Support neurotransmitter rebalancing

• Session dose: 500–1,000 mg per day

• Frequency: daily for 10–14 days during active recovery phase

• Then: 250–500 mg twice weekly for 4 weeks; monthly maintenance

• This is a clinician-supervised inpatient-adjacent protocol — we offer it under strict medical oversight. Not suitable for self-administration under any circumstances.

Post-viral fatigue (Long COVID and similar)

Emerging evidence suggests NAD+ depletion plays a role in post-viral fatigue syndromes. Pilot protocols:

• Session dose: 250–500 mg
• Frequency: twice weekly × 4–6 weeks, then weekly maintenance
• Combine with: glutathione IV, B-complex, Vitamin C

NAD+ IV dosage quick-reference table

Goal	Session dose	Initial frequency	Maintenance
First infusion / introductory	100–250 mg	Once	Assess tolerance
Energy and fatigue	250–500 mg	2× weekly × 4 weeks	Monthly
Anti-ageing / longevity	250–500 mg	1× weekly × 4–6 weeks	Monthly
Cognitive clarity	500 mg	2× weekly × 4 weeks	Monthly
Addiction recovery	500–1,000 mg	Daily × 10–14 days	Weekly then monthly
Post-viral fatigue	250–500 mg	2× weekly × 4–6 weeks	Monthly

All doses and infusion rates are individualised at consultation. The Sculptique Aesthetics does not offer self-administration kits.

NAD+ IV vs oral NMN/NR: which is better?

This is the most asked question about NAD+ therapy and the honest answer is: it depends on the goal.

	NAD+ IV	Oral NMN / NR
Bioavailability	~100 %	10–40 %
Onset of effect	Hours	Days–weeks
Peak NAD+ elevation	High (immediate)	Moderate (gradual)
Duration per dose	3–7 days	Requires daily dosing
Cost	₹8,000–₹25,000 per session	₹3,000–₹8,000/month
Convenience	Clinic visit (2–4 hours)	Daily tablet/capsule
Best for	Acute replenishment, recovery, intensive protocols	Long-term maintenance, prevention, budget-conscious

Our recommendation at The Sculptique Aesthetics: for patients targeting significant energy restoration, anti-ageing or cognitive benefit, begin with an IV loading course (4–6 weekly infusions), then transition to oral NMN/NR for cost-effective daily maintenance, with quarterly IV boosters to refresh cellular levels.

For acute needs (addiction recovery, post-surgery, extreme fatigue) — IV only.

NAD+ IV side effects and how to manage them

The most common reason patients give up on NAD+ IV is the infusion reaction — but this is almost entirely a rate problem, not a dose problem.

Common infusion reactions (rate-dependent)

• Flushing and warmth — feeling of heat, particularly facial; harmless; slow the drip rate
• Chest tightness or pressure — alarming but not dangerous; slow the infusion significantly; usually resolves within minutes
• Nausea — common at faster infusion rates; slow down; small antiemetic dose may be needed for first session
• Headache — mild; typically resolves as infusion completes
• Muscle cramping — often related to rapid mineral shifts; address with pre-hydration and magnesium co-infusion

Rule: NAD+ side effects are almost entirely managed by slowing the infusion rate. A 500 mg infusion given over 4–6 hours is dramatically better tolerated than the same dose over 90 minutes.

Rare and transient

• Palpitations — usually tachycardia during rapid infusion; slow the rate
• Anxiety or restlessness — temporary; slower rate resolves it

Who should be cautious with NAD+ IV

• Haemophilia or active bleeding disorders — IV access risk
• Active cardiovascular instability — slower rates and monitoring required
• Severe renal impairment — metabolite clearance considerations
• Always disclose all medications; certain chemotherapy agents interact with NAD+ metabolism

NAD+ IV at The Sculptique Aesthetics: what to expect

Our Fabulous Drips and NAD+ IV therapy sessions are run in a dedicated wellness suite. Here's the process:

1. Consultation: goals, health history, current medications, baseline energy and cognitive assessment
2. First session: lower introductory dose (100–250 mg), slow rate, clinician present — we calibrate your personal tolerance
3. Subsequent sessions: dose increased per protocol; infusion rate optimised for comfort
4. Concurrent drips: most patients combine NAD+ with glutathione, B-complex, magnesium or Vitamin C in the same session for a comprehensive wellness infusion

See IV drip therapy in Mumbai and IV drips vs peptides for the broader wellness drip context.

Combining NAD+ with peptide therapy

NAD+ IV and peptide therapy are complementary:

• NAD+ + GHK-Cu: anti-ageing combination — NAD+ restores mitochondrial fuel; GHK-Cu rebuilds collagen and skin architecture
• NAD+ + CJC-1295 / Ipamorelin: the complete anti-ageing triad — cellular energy + GH restoration + collagen support
• NAD+ + BPC-157: post-surgical or post-injury — NAD+ supports tissue energy requirements; BPC-157 drives localised repair
• NAD+ + Ozempic / weight-loss protocol: NAD+ counteracts the metabolic fatigue sometimes experienced during GLP-1 dose escalation

At The Sculptique Aesthetics we build combined plans at consultation — you don't need to figure out compatibility alone.

Book your NAD+ IV consultation in Mumbai

Whether you're dealing with persistent fatigue, seeking anti-ageing support, looking for cognitive enhancement, or recovering from illness or surgery, NAD+ IV therapy is one of the most targeted interventions available at The Sculptique Aesthetics.

Contact us to discuss your goals. We'll build the right protocol — whether that's a standalone NAD+ IV course, a combination with glutathione, or a full anti-ageing plan with CJC-1295 / Ipamorelin and GHK-Cu peptide therapy alongside.

Serving patients across Mumbai, Bandra, Khar, Andheri, Powai, Juhu, South Mumbai and international patients travelling to India for medically supervised wellness and IV therapy.