Retatrutide – The Triple-Action Weight Loss Drug Changing the Game

If you thought Ozempic was impressive, Retatrutide is being called “Ozempic on steroids” – not literally, but in terms of its powerful results. Early research shows people losing up to 24% of their body weight – numbers that rival bariatric surgery, without going under the knife.

What is Retatrutide?

Retatrutide is a triple hormone receptor agonist, meaning it targets GLP-1, GIP, and glucagon pathways all at once. Each plays a different role in controlling hunger, metabolism, and fat breakdown. Together, they:

• Suppress appetite so you naturally eat less

• Stabilise blood sugar for fewer cravings

• Increase fat burning while preserving muscle

  
  

How It Works

Most weight-loss medications focus on one or two pathways. Retatrutide is different — by stimulating three separate hormone receptors, it addresses multiple aspects of weight regulation:

• GLP-1: Slows digestion and curbs hunger

• GIP: Enhances the effects of GLP-1 and improves insulin sensitivity

• Glucagon: Encourages fat breakdown and boosts energy use

  
  

Results You Can Expect

In early clinical trials, Retatrutide showed:

• 20–24% average body weight loss in one year

• Significant waist circumference reduction

• Improvements in blood pressure, cholesterol, and blood sugar levels

These results outpace most currently available medications, including Ozempic and Mounjaro.

Side Effects & Safety

Reported side effects are similar to other GLP-1 drugs:

• Nausea, bloating, or mild diarrhoea

• Temporary decreased appetite

• Rarely, injection-site reactions

Because of its impact on multiple metabolic pathways, Retatrutide must be prescribed and monitored by an experienced doctor.

Who Might Benefit from Retatrutide?

It may be an option if you:

• Have a BMI ≥ 30, or ≥ 27 with health issues like type 2 diabetes or hypertension

• Want maximum fat loss without surgery

• Have not achieved results with other medications like Ozempic or Mounjaro

Retatrutide vs. Ozempic / Mounjaro

Feature	Retatrutide	Ozempic	Mounjaro
Hormones Targeted	GLP-1, GIP, Glucagon	GLP-1	GLP-1, GIP
Avg. Weight Loss	20–24% in 12–18 months	10–15% in 12–18 months	15–20% in 12–18 months
Muscle Preservation	High	Moderate	High
Main Action	Appetite control + fat burn	Appetite control	Appetite control + insulin sensitivity

Maximising Results

Even with Retatrutide, lifestyle habits matter:

• Protein-rich diet to support lean muscle

• Regular strength and cardio training for lasting fat loss

• Consistent sleep and hydration to keep metabolism optimal

Bottom Line: Retatrutide could be the future of medical weight loss — combining triple hormonal action for unmatched fat loss while protecting muscle. It’s still under clinical review in many countries, but early results are extremely promising.

📍 Book your consultation at The Sculptique Aesthetics to learn about Retatrutide and other advanced weight-loss options.